|
Mutation Information
|
Mutation Site
|
M41L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
abacavir (ABC);lamivudine (LAM);dolutegravir (DTG) |
|
Country
|
French;Italy;Netherlands;Swiss |
Literature Information
|
PubMed PMID
|
31660328
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
Open forum infectious diseases |
|
Title
|
Impact of the M184V/I Mutation on the Efficacy of Abacavir/Lamivudine/Dolutegravir Therapy in HIV Treatment-Experienced Patients. |
|
Author
|
Olearo F,Nguyen H,Bonnet F,Yerly S,Wandeler G,Stoeckle M,Cavassini M,Scherrer A,Costagiola D,Schmid P,Günthard HF,Bernasconi E,Boeni J,D'arminio Monforte A,Zazzi M,Rossetti B,Neau D,Bellecave P,Rijnders B,Reiss P,Wit F,Kouyos R,Calmy A |
|
Evidence
|
Among the 21 patients who experienced VF, 2 had 3 archived TAMs (D67N, K70R, and K219Q/E and M41L, K70R, and K219Q/E), including the M184V/I mutation.
|
|
|
HIV Mutation Detail Information