HIV Mutation Detail Information

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Mutation Information

Mutation Site	M41L
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	efavirenz (EFV);tenofovir (TDF);emtricitabine (FTC)
Country	US;Thailand

Literature Information

PubMed PMID	30951600
Disease	HIV infection/AIDS
Published Year	2020
Journal	Journal of the Pediatric Infectious Diseases Society
Title	Long-Term Safety and Efficacy of Dolutegravir in Treatment-Experienced Adolescents With Human Immunodeficiency Virus Infection: Results of the IMPAACT P1093 Study.
Author	Viani RM,Ruel T,Alvero C,Fenton T,Acosta EP,Hazra R,Townley E,Palumbo P,Buchanan AM,Vavro C,Singh R,Graham B,Anthony P,George K,Wiznia A,P1093 Study Team .
Evidence	There was no evolution in RT-associated mutations in any participants except participant 18, who, while taking TDF, FTC, and EFV, had emergent multiple nucleoside RT inhibitor–associated mutations M41L and T215F/L but no EFV-associated mutation at week 192 (Table 4).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation