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Mutation Information
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Mutation Site
|
M41L |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
zidovudine (AZT);tenofovir (TDF) |
|
Country
|
Cameroon |
Literature Information
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PubMed PMID
|
30871487
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2019 |
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Journal
|
BMC infectious diseases |
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Title
|
HIV-1 drug resistance testing is essential for heavily-treated patients switching from first- to second-line regimens in resource-limited settings: evidence from routine clinical practice in Cameroon. |
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Author
|
Takou D,Fokam J,Teto G,Santoro MM,Ceccherini-Silberstein F,Nanfack AJ,Sosso SM,Dambaya B,Salpini R,Billong SC,Gori C,Fokunang CN,Cappelli G,Colizzi V,Perno CF,Ndjolo A |
|
Evidence
|
Thymidine-analogue mutations (TAMs)-1 [T215FY (46.53%), M41 L (22.77%), L210 W (8.91%)], with cross-resistance to AZT and TDF, were higher compared to TAMs-2 [D67N (21.78%), K70R (19.80%), K219QE (18.81%)].
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HIV Mutation Detail Information