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Mutation Information
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Mutation Site
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M41L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
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A1;B;URF |
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Relevant Drug
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NRTIs |
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Country
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German |
Literature Information
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PubMed PMID
|
30650082
|
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Disease
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HIV infection/AIDS
|
|
Published Year
|
2019 |
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Journal
|
PloS one |
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Title
|
Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort. |
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Author
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Machnowska P,Meixenberger K,Schmidt D,Jessen H,Hillenbrand H,Gunsenheimer-Bartmeyer B,Hamouda O,Kücherer C,Bannert N,German HIV-1 Seroconverter Study Group. |
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Evidence
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Viral susceptibility to NNRTIs (6.5%-6.9% for individual drugs) was mainly reduced, while <3% of the recommended NRTIs and PIs were affected. The longest mean survival times were calculated for the NNRTI mutations K103N (5.3 years, 95% CI 4.2-5.6) and E138A/G/K (8.0 years, 95% CI 5.8-10.2 / 7.9 years, 95% CI 5.4-10.3 / 6.7 years, 95% CI 6.7-6.7) and for the NRTI mutation M41L (6.4 years, 95% CI 6.0-6.7).
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HIV Mutation Detail Information