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Mutation Information
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Mutation Site
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M36I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
Literature Information
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PubMed PMID
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27039930
|
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Published Year
|
2016 |
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Journal
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Biochemistry |
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Title
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Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme. |
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Author
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Park JH,Sayer JM,Aniana A,Yu X,Weber IT,Harrison RW,Louis JM |
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Evidence
|
Other mutations in this region, E35D and M36I in both mutants, and S37D in PRS17, are located in the flap hinge loop and likely contribute to altered flap conformation and dynamics.
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HIV Mutation Detail Information