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Mutation Information
|
Mutation Site
|
M36I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Genotype/Subtype
|
A;C;D;F;G;CRF01_AE;CRF02_AG |
|
Viral Reference
|
M62320;
K03455;
U46016;
M27323;
AF005494;
AF061642;
AF005496;
AF082394;
AJ249235;
U54771;
L39106;
AJ006022;
L20587 |
|
Relevant Drug
|
PIs |
Literature Information
|
PubMed PMID
|
15839752
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2005 |
|
Journal
|
PLoS medicine |
|
Title
|
Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration. |
|
Author
|
Kantor R,Katzenstein DA,Efron B,Carvalho AP,Wynhoven B,Cane P,Clarke J,Sirivichayakul S,Soares MA,Snoeck J,Pillay C,Rudich H,Rodrigues R,Holguin A,Ariyoshi K,Bouzas MB,Cahn P,Sugiura W,Soriano V,Brigido LF,Grossman Z,Morris L,Vandamme AM,Tanuri A,Phanuphak P,Weber JN,Pillay D,Harrigan PR,Camacho R,Schapiro JM,Shafer RW |
|
Evidence
|
Subtype-specific polymorphisms at four protease and three RT drug-resistance positions represented the consensus sequence for at least one non-B subtype: K20I in subtypes G and CRF02_AG, M36I in subtypes A, C, D, F, G, CRF01_AE and CRF02_AG, V82I in subtype G, and I93L in subtype C for protease;and A98S in subtype G, V179I in subtype A, and K238R in CRF01_AE for RT.
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HIV Mutation Detail Information