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Mutation Information
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Mutation Site
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M271I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Env |
Literature Information
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PubMed PMID
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32748788
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Published Year
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2020 |
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Journal
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eLife |
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Title
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Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens. |
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Author
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Ueda G,Antanasijevic A,Fallas JA,Sheffler W,Copps J,Ellis D,Hutchinson GB,Moyer A,Yasmeen A,Tsybovsky Y,Park YJ,Bick MJ,Sankaran B,Gillespie RA,Brouwer PJ,Zwart PH,Veesler D,Kanekiyo M,Graham BS,Sanders RW,Moore JP,Klasse PJ,Ward AB,King NP,Baker D |
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Evidence
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BG505 SOSIP variant used for all early optimizations steps was engineered with a combination of v5.2 (mutations: E64K, A73C, A316W, A561C) and MD3D (mutations: M271I, A318Y, R585H, L568D, V570H, R304V, F519S) stabilizing mutations, and had glycosylation sites introduced at positions 241 and 289 (mutations: P240T, S241N, F288L, T290E, P291S).
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HIV Mutation Detail Information