|
Mutation Information
|
Mutation Site
|
M230L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
etravirine(ETR) |
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
32071061
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Discordance between Etravirine Phenotype and Genotype-Based Predicted Phenotype for Subtype C HIV-1 from First-Line Antiretroviral Therapy Failures in South Africa. |
|
Author
|
McCormick KD,Penrose KJ,Brumme CJ,Harrigan PR,Viana RV,Mellors JW,Parikh UM,Wallis CL |
|
Evidence
|
Mutations L100I, Y181C, or M230L were present in 27/34 (79%) of samples with an FC of >10 but only in 2/46 (4%) of samples with an FC of <2.9.
|
|
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HIV Mutation Detail Information