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Mutation Information
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Mutation Site
|
M230L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
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NNRTIs |
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Country
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Haiti |
Literature Information
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PubMed PMID
|
30640198
|
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Disease
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HIV infection/AIDS
|
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Published Year
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2019 |
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Journal
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The Pediatric infectious disease journal |
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Title
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High Levels of HIV-1 Drug Resistance in Children Who Acquired HIV Infection Through Mother to Child Transmission in the Era of Option B+, Haiti, 2013 to 2014. |
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Author
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Louis FJ,Segaren N,Desinor O,Beard RS,Jean-Louis R,Chang J,Boisson S,Hulland EN,Wagar N,DeVos J,François K,Buteau J,Boncy J,Marston BJ,Domerçant JW,Yang C,Charles M |
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Evidence
|
Moreover, 121 (39.8%) children harbored viruses with DR mutations conferring resistance to both NRTIs and NNRTIs, and 122 (40.1%) had two or more NNRTI mutations. Twenty-nine (9.5%) of the children had additional NNRTI mutations (A98G, E138A/G/K/Q, H221Y, and M230L) that confer resistance to second generation NNRTI drugs etravirine and rilpivirine.
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HIV Mutation Detail Information