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Mutation Information
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Mutation Site
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M184V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.G190S+rt.M184V |
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Country
|
Russia |
Literature Information
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PubMed PMID
|
33136751
|
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Disease
|
HIV infection/AIDS
|
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Published Year
|
2020 |
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Journal
|
Journal of acquired immune deficiency syndromes (1999) |
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Title
|
Long-Acting Injectable Cabotegravir + Rilpivirine for HIV Maintenance Therapy: Week 48 Pooled Analysis of Phase 3 ATLAS and FLAIR Trials. |
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Author
|
Rizzardini G,Overton ET,Orkin C,Swindells S,Arasteh K,Górgolas Hernández-Mora M,Pokrovsky V,Girard PM,Oka S,Andrade-Villanueva JF,Richmond GJ,Baumgarten A,Masiá M,Latiff G,Griffith S,Harrington CM,Hudson KJ,St Clair M,Talarico CL,Patel P,Cutrell A,Van Eygen V,D'Amico R,Mrus JM,Wu S,Ford SL,Chow K,Roberts J,Wills A,Walters N,Vanveggel S,Van Solingen-Ristea R,Crauwels H,Smith KY,Spreen WR,Margolis DA |
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Evidence
|
In ATLAS, there were 4 CVFs in the CAR arm, 3 of whom had reverse transcriptase mutations (M184I; M184V + G190S; and M230M/I) detected in HIV-1 RNA samples from 1 participant each, and 1 had no mutations.
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HIV Mutation Detail Information