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Mutation Information
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Mutation Site
|
M184V |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Country
|
Mexico |
Literature Information
|
PubMed PMID
|
32205723
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
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Journal
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AIDS (London, England) |
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Title
|
Near point-of-care, point-mutation test to detect drug resistance in HIV-1: a validation study in a Mexican cohort. |
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Author
|
Panpradist N,Beck IA,Ruth PS,Ávila-Ríos S,García-Morales C,Soto-Nava M,Tapia-Trejo D,Matías-Florentino M,Paz-Juarez HE,Del Arenal-Sanchez S,Reyes-Terán G,Lutz BR,Frenkel LM |
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Evidence
|
For example, the M184V resistance mutation in HIV-1 RT is known to increase fidelity, impair viral fitness, and increase hyper-sensitization to NRTIs (such as amprenavir and efavirenz).
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HIV Mutation Detail Information