|
Mutation Information
|
Mutation Site
|
M184V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Country
|
African American;African heritage;Asian |
Literature Information
|
PubMed PMID
|
31905383
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
|
Title
|
Efficacy and Safety of Switching to Dolutegravir/Lamivudine Fixed-Dose 2-Drug Regimen vs Continuing a Tenofovir Alafenamide-Based 3- or 4-Drug Regimen for Maintenance of Virologic Suppression in Adults Living With Human Immunodeficiency Virus Type 1: Phase 3, Randomized, Noninferiority TANGO Study. |
|
Author
|
van Wyk J,Ajana F,Bisshop F,De Wit S,Osiyemi O,Portilla Sogorb J,Routy JP,Wyen C,Ait-Khaled M,Nascimento MC,Pappa KA,Wang R,Wright J,Tenorio AR,Wynne B,Aboud M,Gartland MJ,Smith KY |
|
Evidence
|
Preexisting archived M184V/I (all detected as mixtures with wild-type) was observed in 4/322 participants in the DTG/3TC group and 3/321 in the TAF-based regimen group.
|
|
|
HIV Mutation Detail Information