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HIV Mutation Detail Information

> M184V Search Result


Mutation Information
Mutation Site M184V
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Relevant Drug emtricitabine(FTC);lamivudine (LAM)
Literature Information
PubMed PMID 31872074
Published Year 2019
Journal Communications biology
Title Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance.
Author Hung M,Tokarsky EJ,Lagpacan L,Zhang L,Suo Z,Lansdon EB
Evidence Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistanceEmtricitabine (FTC) and lamivudine (3TC), containing an oxathiolane ring with unnatural (-)-stereochemistry, are widely used nucleoside reverse transcriptase inhibitors (NRTIs) in anti-HIV therapy.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation