HIV Mutation Detail Information

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Mutation Information

Mutation Site	M184V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	B
Relevant Drug	NRTIs

Literature Information

PubMed PMID	31591964
Disease	HIV infection/AIDS
Published Year	2019
Journal	eLife
Title	Epistasis and entrenchment of drug resistance in HIV-1 subtype B.
Author	Biswas A,Haldane A,Arnold E,Levy RM
Evidence	Most drug-resistance mutations against all four classes of drugs are usually present only at low frequencies (much lower than 50% with the one exception of M184V in RT) in the drug-experienced dataset (Table 2:source datas 1, 2, 3, 4);but many of these mutations (with the exception of those conferring resistance to the NNRTIs) are highly 'entrenched in the population' of sequences where they do occur (Table 2), meaning that the mutation is more likely than the wild-type residue in these particular backgrounds, with low probability of reversion.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation