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Mutation Information
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Mutation Site
|
M184V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M230I+rt.M184V |
|
Relevant Drug
|
emtricitabine (FTC) |
Literature Information
|
PubMed PMID
|
30894467
|
|
Published Year
|
2019 |
|
Journal
|
Journal of virology |
|
Title
|
Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs. |
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Author
|
Boyer PL,Melody K,Smith SJ,Dunn LL,Kline C,Fischer DK,Dwivedi R,Clark P,Hughes SH,Ambrose Z |
|
Evidence
|
Addition of the FTC resistance mutation M184V to M230I (M184V/M230I HIV-1) produced the expected loss of susceptibility to FTC but did not affect the susceptibility of the virus to AZT or RPV (data not shown).
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HIV Mutation Detail Information