HIV Mutation Detail Information

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Mutation Information

Mutation Site	M184V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	A
Relevant Drug	dolutegravir (DTG)
Country	Canada

Literature Information

PubMed PMID	27367488
Disease	HIV infection/AIDS
Published Year	2016
Journal	AIDS (London, England)
Title	The M184I/V and K65R nucleoside resistance mutations in HIV-1 prevent the emergence of resistance mutations against dolutegravir.
Author	Oliveira M,Ibanescu RI,Pham HT,Brenner B,Mesplède T,Wainberg MA
Evidence	METHODS: We performed tissue culture selection experiments using reverse transcriptase inhibitor-resistant viruses containing resistance substitutions at positions K65R, M184I or M184V in the presence of increasing concentrations of RAL, EVG or DTG and monitored changes in integrase sequences by genotyping.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation