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Mutation Information
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Mutation Site
|
M184V |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
NRTIs |
Literature Information
|
PubMed PMID
|
27130466
|
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Published Year
|
2016 |
|
Journal
|
Retrovirology |
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Title
|
Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses. |
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Author
|
Pham HT,Mesplède T,Wainberg MA |
|
Evidence
|
The addition of DTG-resistance substitutions reduces viral infectiousness in viruses containing the K65R, L74V, K103N, E138K or M184V/I reverse transcriptase mutationsAs previously hypothesized, the fitness cost of the H5Y/R263K combination may have a benefit for patients under DTG treatment in terms of viral load.
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HIV Mutation Detail Information