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HIV Mutation Detail Information

> M184V Search Result


Mutation Information
Mutation Site M184V
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Relevant Drug azvudine (FNC);lamivudine (LAM)
Literature Information
PubMed PMID 25144636
Published Year 2014
Journal PloS one
Title Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro.
Author Wang RR,Yang QH,Luo RH,Peng YM,Dai SX,Zhang XJ,Chen H,Cui XQ,Liu YJ,Huang JF,Chang JB,Zheng YT
Evidence Although M184V caused 250 fold reduction in susceptibility, azvudine remained active at nanomolar range.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation