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Mutation Information
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Mutation Site
|
M184I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
NNRTIs |
|
Country
|
Nigeria |
Literature Information
|
PubMed PMID
|
33143751
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
AIDS research and therapy |
|
Title
|
Predictors of first-line antiretroviral therapy failure among adults and adolescents living with HIV/AIDS in a large prevention and treatment program in Nigeria. |
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Author
|
Ndembi N,Murtala-Ibrahim F,Tola M,Jumare J,Aliyu A,Alabi P,Mensah C,Abimiku A,Quiñones-Mateu ME,Crowell TA,Rhee SY,Shafer RW,Gupta R,Blattner W,Charurat ME,Dakum P |
|
Evidence
|
Of 198 patient-derived samples sequenced during virologic failure, 42 (21%) were wild-type;145 (73%) carried NNRTI drug resistance mutations;151 (76.3%) M184I/V;29 (14.6%) had >/= 3 TAMs, and 37 (18.7%) had K65R, of whom all were on TDF-containing first-line regimens.
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HIV Mutation Detail Information