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Mutation Information
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Mutation Site
|
M184I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
emtricitabine(FTC);lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
31872074
|
|
Published Year
|
2019 |
|
Journal
|
Communications biology |
|
Title
|
Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance. |
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Author
|
Hung M,Tokarsky EJ,Lagpacan L,Zhang L,Suo Z,Lansdon EB |
|
Evidence
|
There appears to be a small shift in the primer 3'-terminal nucleotide in response to the mutation which was also observed in the previous binary structure of M184I RT bound to DNA.
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HIV Mutation Detail Information