HIV Mutation Detail Information

> M184I Search Result

Mutation Information

Mutation Site	M184I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	azvudine (FNC);lamivudine (LAM)

Literature Information

PubMed PMID	25144636
Published Year	2014
Journal	PloS one
Title	Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro.
Author	Wang RR,Yang QH,Luo RH,Peng YM,Dai SX,Zhang XJ,Chen H,Cui XQ,Liu YJ,Huang JF,Chang JB,Zheng YT
Evidence	In in vitro induced resistant assay, the frequency of M184I mutation increased with induction time which suggests M184I as the key mutation in azvudine treatment.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation