|
Mutation Information
|
Mutation Site
|
M133L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
A |
|
Immune Escape
|
Y |
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
29414186
|
|
Disease
|
HBV infection
|
|
Published Year
|
2018 |
|
Journal
|
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
|
Title
|
Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay. |
|
Author
|
Gencay M,Vermeulen M,Neofytos D,Westergaard G,Pabinger S,Kriegner A,Seffner A,Gohl P,Huebner K,Nauck M,Kaminski WE |
|
Evidence
|
All Occult hepatitis B-associated Y100C and common diagnostic and vaccine-escape-associated P120T, G145R, K122R, M133L, M133T, Q129H, G130N, and T126S mutations were reliably detected by the assay, which consistently detected the presence of HBsAg in all 179 samples including samples with 11 novel mutations.
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HBV Mutation Detail Information