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Mutation Information
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Mutation Site
|
M133L |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
S |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
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PubMed PMID
|
12167344
|
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Published Year
|
2002 |
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Journal
|
Virology |
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Title
|
Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S gene. |
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Author
|
Torresi J,Earnest-Silveira L,Civitico G,Walters TE,Lewin SR,Fyfe J,Locarnini SA,Manns M,Trautwein C,Bock TC |
|
Evidence
|
In contrast, the HBV a determinant HBIg/vaccine escape mutants sP120T, sT123N, sG145R, and sD144E/G145R (that produce rtT128N, Q130P, rtW153Q, and rtG153E respectively) yielded as much virus as wild-type HBV while the sM133L (rtY141S) mutant was replication impaired.
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HBV Mutation Detail Information