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Mutation Information
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Mutation Site
|
L90M |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
Literature Information
|
PubMed PMID
|
32309558
|
|
Published Year
|
2014 |
|
Journal
|
Discoveries (Craiova, Romania) |
|
Title
|
The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics. |
|
Author
|
Chordia P,Dewdney TG,Keusch B,Kuiper BD,Ross K,Kovari IA,MacArthur R,Salimnia H,Kovari LC |
|
Evidence
|
We identify a novel structural role for the I47V, V32I, I54M and L90M major resistance mutations in flap opening and closure of MDR-PR isolates.
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HIV Mutation Detail Information