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Mutation Information
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Mutation Site
|
L90M |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
Literature Information
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PubMed PMID
|
18597780
|
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Published Year
|
2008 |
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Journal
|
Journal of molecular biology |
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Title
|
Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. |
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Author
|
Liu F,Kovalevsky AY,Tie Y,Ghosh AK,Harrison RW,Weber IT |
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Evidence
|
However, the crystal structure of the double mutant PRG48V/L90M with SQV (1FB7) shows that saquinavir moves to accommodate the bigger side chain of Val48, giving rise to weaker interactions than in the PR-SQV structure.
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HIV Mutation Detail Information