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Mutation Information
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Mutation Site
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L8I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gag |
Literature Information
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PubMed PMID
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33485964
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Published Year
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2021 |
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Journal
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The Journal of biological chemistry |
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Title
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Structural characterization of HIV-1 matrix mutants implicated in envelope incorporation. |
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Author
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Eastep GN,Ghanam RH,Green TJ,Saad JS |
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Evidence
|
Subsequent NMR studies revealed that point mutations in the N-terminal region of MA (e.g., V7R, L8A, or L8I) that impaired membrane targeting of Gag and inhibited virus assembly and release did not exhibit concentration-dependent myristate exposure. Structural data revealed conformational changes that appeared to be responsible for stabilizing the myristate-sequestered species and inhibiting exposure.
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HIV Mutation Detail Information