HIV Mutation Detail Information

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Mutation Information

Mutation Site	L89M
Mutation Type	Amino acid level
Gene/Protein/Region Type	PR
Combined Mutation	pr.L89M+pr.G48T
Relevant Drug	nelfinavir (NFV)

Literature Information

PubMed PMID	32057044
Published Year	2020
Journal	Physical chemistry chemical physics : PCCP
Title	Revealing the binding and drug resistance mechanism of amprenavir, indinavir, ritonavir, and nelfinavir complexed with HIV-1 protease due to double mutations G48T/L89M by molecular dynamics simulations and free energy analyses.
Author	Wang RG,Zhang HX,Zheng QC
Evidence	Revealing the binding and drug resistance mechanism of amprenavir, indinavir, ritonavir, and nelfinavir complexed with HIV-1 protease due to double mutations G48T/L89M by molecular dynamics simulations and free energy analyses.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation