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Mutation Information
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Mutation Site
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L855A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gp41 |
Literature Information
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PubMed PMID
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21569545
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Published Year
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2011 |
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Journal
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Retrovirology |
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Title
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Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity. |
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Author
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Bhakta SJ,Shang L,Prince JL,Claiborne DT,Hunter E |
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Evidence
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Mutations in S1 (L765H), S2 (Y768S), S3 (LLLI774SHSN), and S4 (LL784HQ) are located in the N-terminus (S1, S2), middle (S3) and C-terminus (S4) of the LLP2 motif. Mutants S5 (YW795SL), S6 (LL799HQ), S7 (YW802SL), S8 (LL814AA), and S9 (LL855AA) target the other Y- and LL-motifs downstream of the "three-pin" motif.
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HIV Mutation Detail Information