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Mutation Information
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Mutation Site
|
L83V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV16 |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
24150786
|
|
Disease
|
High grade squamous intraepithelial lesion;
Low grade squamous intraepithelial lesion;
Cervical carcinoma
|
|
Published Year
|
2014 |
|
Journal
|
Journal of medical virology |
|
Title
|
Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants. |
|
Author
|
Hang D,Gao L,Sun M,Liu Y,Ke Y |
|
Evidence
|
By Western blot analysis, a similar ability to degrade p53 was observed among EUR E6, As E6, EUR E6-L83V and As E6-E113D. A rare variation, EUR E6-R10G, was found to shorten the half-life of p53 more efficiently than the other variations.
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HPV Mutation Detail Information