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Mutation Information
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Mutation Site
|
L83V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Amino acid_Mutation
|
T350G |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
NC_001526.1
|
|
Country
|
Sweden |
Literature Information
|
PubMed PMID
|
22558401
|
|
Disease
|
Squamous-cell carcinoma;
Head and neck carcinoma;
Cervical carcinoma
|
|
Published Year
|
2012 |
|
Journal
|
PloS one |
|
Title
|
Human papillomavirus (HPV) 16 E6 variants in tonsillar cancer in comparison to those in cervical cancer in Stockholm, Sweden. |
|
Author
|
Du J,Nordfors C,Näsman A,Sobkowiak M,Romanitan M,Dalianis T,Ramqvist T |
|
Evidence
|
The rare E6 variant R10G was relatively frequent (19%) in TSCC, absent in CC and infrequent (4%) in CS, while the well-known L83V variant was common in TSCC (40%), CC (31%), and CS (29%). The difference for R10G was significant between TSCC and CC (p = 0.0003), as well as between TSCC and CS (p = 0.009).
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HPV Mutation Detail Information