|
Mutation Information
|
Mutation Site
|
L83V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Combined Mutation
|
e6.Q14H+e6.H78Y+e6.L83V;e6.R10G+e6.L83V |
|
Genotype/Subtype
|
HPV16 |
|
Country
|
Scandinavia |
Literature Information
|
PubMed PMID
|
18986660
|
|
Published Year
|
2009 |
|
Journal
|
Virology |
|
Title
|
Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis. |
|
Author
|
Zehbe I,Richard C,DeCarlo CA,Shai A,Lambert PF,Lichtig H,Tommasino M,Sherman L |
|
Evidence
|
We evaluated functions relevant to carcinogenesis for the E6 variants L83V, R10/L83V and Q14H/H78Y/L83V as well as the prototype in a model of human normal immortalized keratinocytes (NIKS).
|
|
|
HPV Mutation Detail Information