|
Mutation Information
|
Mutation Site
|
L83V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV16 |
|
Country
|
Sweden |
Literature Information
|
PubMed PMID
|
12691704
|
|
Disease
|
Cervical carcinoma
|
|
Published Year
|
2003 |
|
Journal
|
Human immunology |
|
Title
|
Association between human papillomavirus 16 E6 variants and human leukocyte antigen class I polymorphism in cervical cancer of Swedish women. |
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Author
|
Zehbe I,Mytilineos J,Wikström I,Henriksen R,Edler L,Tommasino M |
|
Evidence
|
Women with HLA-B*44, HLA-B*51, or HLA-B*57 who were infected with the HPV16 E6 variant L83V had an approximately four- to fivefold increased risk for cancer compared with controls (odds ratio [OR] = 3.5, 95% CI = 1.1-11.1, OR = 4.2, 95% CI = 1.19-14.69, or OR = 4.67, 95% CI = 1.2-18.6, respectively).
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HPV Mutation Detail Information