HIV Mutation Detail Information

> L771S Search Result

Mutation Information

Mutation Site	L771S
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp41

Literature Information

PubMed PMID	21569545
Published Year	2011
Journal	Retrovirology
Title	Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity.
Author	Bhakta SJ,Shang L,Prince JL,Claiborne DT,Hunter E
Evidence	Subsequent mutagenesis of the third pin (L771S) and the LL774LI776 motifs resulted in a significant decrease in fusion compared to WT, with B and YB reducing fusogenicity to 41% and 35% of WT respectively.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation