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Mutation Information
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Mutation Site
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L76V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Nef |
Literature Information
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PubMed PMID
|
22651890
|
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Published Year
|
2012 |
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Journal
|
Retrovirology |
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Title
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Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix. |
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Author
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Kuo LS,Baugh LL,Denial SJ,Watkins RL,Liu M,Garcia JV,Foster JL |
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Evidence
|
L76V, and possibly P78G, have a small negative effect on Nef/activated PAK2 complex formation, but in sharp contrast to Nef-Hck SH3 binding, F90A eliminated it.
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HIV Mutation Detail Information