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Mutation Information
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Mutation Site
|
L75G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gag |
Literature Information
|
PubMed PMID
|
33485964
|
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Published Year
|
2021 |
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Journal
|
The Journal of biological chemistry |
|
Title
|
Structural characterization of HIV-1 matrix mutants implicated in envelope incorporation. |
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Author
|
Eastep GN,Ghanam RH,Green TJ,Saad JS |
|
Evidence
|
Nonconservative mutations in the trimer interface of MA (A45E, T70R, and L75G) were found to impair Env incorporation and infectivity, leading to the hypothesis that MA trimerization is an obligatory step for Env incorporation.
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HIV Mutation Detail Information