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Mutation Information
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Mutation Site
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L74V |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
NRTIs |
|
Country
|
Europe;Sub‐Saharan Africa;South America;Middle East;South‐east Asia |
Literature Information
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PubMed PMID
|
32964671
|
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Disease
|
HIV infection/AIDS
|
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Published Year
|
2021 |
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Journal
|
HIV medicine |
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Title
|
Transmitted drug resistance to NRTIs and risk of virological failure in naïve patients treated with integrase inhibitors. |
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Author
|
Borghetti A,Ciccullo A,Lombardi F,Baldin G,Belmonti S,Prosperi M,Incardona F,Heger E,Borghi V,Sönnerborg A,Zazzi M,De Luca A,Di Giambenedetto S |
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Evidence
|
Among TDRMs with a potential impact on the NRTI employed, M184V/I was the most frequent (19 cases, 1.7%), followed by M41L (17 cases, 1.6%), T215F/Y (five cases, 0.5%), L74V (four cases, 0.4%), L210W (four cases, 0.4%), Y115F (three cases, 0.3%), K70R (three cases, 0.3%) and K65R (two cases, 0.2%).
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HIV Mutation Detail Information