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Mutation Information
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Mutation Site
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L74M |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
IN |
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Country
|
France |
Literature Information
|
PubMed PMID
|
33693680
|
|
Clinical information
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Yes
|
|
Disease
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HIV infection/AIDS
|
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Published Year
|
2021 |
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Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
No difference in HIV-1 integrase inhibitor resistance between CSF and blood compartments. |
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Author
|
Abdi B,Chebbi M,Wirden M,Teyssou E,Sayon S,Palich R,Seang S,Valantin MA,Simon A,Tubiana R,Katlama C,Calvez V,Marcelin AG,Soulie C |
|
Evidence
|
The HIV-1 integrase sequences from CSF presented resistance mutations for 9/27 (33.3%) and 8/32 (25.0%) for ARV-naive (L74I, n = 3; L74I/M, n = 1; T97A, n = 1; E157Q, n = 4) and ARV-treated (L74I, n = 6; L74M, n = 1; T97A, n = 1; N155H, n = 1) patients, respectively.
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HIV Mutation Detail Information