|
Mutation Information
|
Mutation Site
|
L74M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
NL4.3
|
|
Relevant Drug
|
dolutegravir (DTG) |
|
Country
|
Uganda |
Literature Information
|
PubMed PMID
|
32853364
|
|
Clinical information
|
Yes
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Accumulation of integrase strand transfer inhibitor resistance mutations confers high-level resistance to dolutegravir in non-B subtype HIV-1 strains from patients failing raltegravir in Uganda. |
|
Author
|
Ndashimye E,Avino M,Olabode AS,Poon AFY,Gibson RM,Li Y,Meadows A,Tan C,Reyes PS,Kityo CM,Kyeyune F,Nankya I,Quiñones-Mateu ME,Arts EJ |
|
Evidence
|
A combination of two primary INSTI DRMs (Q148H and G140S) with secondary mutations (T97A and L74M) conferred resistance to dolutegravir in subtype B viruses
|
|
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HIV Mutation Detail Information