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Mutation Information
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Mutation Site
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L74M |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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IN |
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Relevant Drug
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raltegravir (RAL);etravirine(ETR);darunavir (DRV);ritonavir;enfuvirtide (T20);elvitegravir (EVG) |
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Country
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France |
Literature Information
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PubMed PMID
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20436677
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Disease
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HIV infection/AIDS
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Published Year
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2010 |
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Journal
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PloS one |
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Title
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The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions. |
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Author
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Reigadas S,Anies G,Masquelier B,Calmels C,Stuyver LJ,Parissi V,Fleury H,Andreola ML |
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Evidence
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In all three patients, the initial selection of the N155H mutation was followed by its disappearance and replacement by a pattern comprising the Y143H/R/C mutations with other mutations (T97A in 3 patients, L74M in 2 patients and G163R and S230R in one patient each); RAL was stopped between months 6 and 12 in patient 1, with disappearance of the selected mutations.
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HIV Mutation Detail Information