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Mutation Information
|
Mutation Site
|
L74L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
INSTIs |
|
Country
|
Finland |
Literature Information
|
PubMed PMID
|
28212411
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2017 |
|
Journal
|
PloS one |
|
Title
|
Lack of impact of pre-existing T97A HIV-1 integrase mutation on integrase strand transfer inhibitor resistance and treatment outcome. |
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Author
|
Abram ME,Ram RR,Margot NA,Barnes TL,White KL,Callebaut C,Miller MD |
|
Evidence
|
The 2 TE patients with the highest EVG FC values (9.94 and 8.95) developed T97A on RAL+ABC+LPV/r and co-developed the secondary INSTI RAM, L74M (or L74L/M).
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HIV Mutation Detail Information