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Mutation Information
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Mutation Site
|
L74I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
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Viral Reference
|
HXB2
|
|
Country
|
Uganda |
Literature Information
|
PubMed PMID
|
33635845
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2021 |
|
Journal
|
AIDS (London, England) |
|
Title
|
Pre-treatment integrase inhibitor resistance is uncommon in antiretroviral therapy-naive individuals with HIV-1 subtype A1 and D infections in Uganda. |
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Author
|
McCluskey SM,Kamelian K,Musinguzi N,Kigozi S,Boum Y 2nd,Bwana MB,Muzoora C,Brumme ZL,Carrington M,Carlson J,Foley B,Hunt PW,Martin JN,Bangsberg DR,Harrigan PR,Siedner MJ,Haberer JE,Lee GQ |
|
Evidence
|
HLA genotypes A *02:01/05/14, B *44:15, and C *04:07 predicted the presence of L74I, a mutation recently observed in association with long-acting INSTI cabotegravir virologic failure.
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HIV Mutation Detail Information