|
Mutation Information
|
Mutation Site
|
L74I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NRTIs |
|
Country
|
Uganda |
Literature Information
|
PubMed PMID
|
32005262
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
AIDS research and therapy |
|
Title
|
Comparison of HIV drug resistance profiles across HIV-1 subtypes A and D for patients receiving a tenofovir-based and zidovudine-based first line regimens in Uganda. |
|
Author
|
Ayitewala A,Kyeyune F,Ainembabazi P,Nabulime E,Kato CD,Nankya I |
|
Evidence
|
As expected, discriminatory DRMs such as K65R, L74I, and Y115F were noted in Tenofovir (TDF) containing regimens while the Thymidine Analogue Mutations (TAMs) L210W and T215 mutations were in Zidovudine (AZT)-based regimens.
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HIV Mutation Detail Information