HIV Mutation Detail Information

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Mutation Information

Mutation Site	L74I
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	A
Viral Reference	K03455.1
Relevant Drug	NRTIs

Literature Information

PubMed PMID	31885806
Published Year	2019
Journal	Oxidative medicine and cellular longevity
Title	HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist.
Author	Bayurova E,Jansons J,Skrastina D,Smirnova O,Mezale D,Kostyusheva A,Kostyushev D,Petkov S,Podschwadt P,Valuev-Elliston V,Sasinovich S,Korolev S,Warholm P,Latanova A,Starodubova E,Tukhvatulin A,Latyshev O,Selimov R,Metalnikov P,Komarov A,Ivanova O,Gorodnicheva T,Kochetkov S,Gottikh M,Strumfa I,Ivanov A,Gordeychuk I,Isaguliants M
Evidence	The most frequent mutation of resistance to NRTI worldwide is M184V/I, followed by K65R/N, L74V/I, Y115F, and Q151M, and the most prevalent for FSU_A is M184V, followed by K65R/N.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation