|
Mutation Information
|
Mutation Site
|
L74I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NRTIs |
|
Country
|
America |
Literature Information
|
PubMed PMID
|
29846534
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
|
Title
|
Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted Human Immunodeficiency Virus Type 1 Drug Resistance in a Large US Clinic Population. |
|
Author
|
Rhee SY,Clutter D,Fessel WJ,Klein D,Slome S,Pinsky BA,Marcus JL,Hurley L,Silverberg MJ,Kosakovsky Pond SL,Shafer RW |
|
Evidence
|
The non-TAMs K65R, L74V/I, Y115F, and Q151M each occurred in just 1 or 2 individuals. The TDF-associated SDRM K70E did not occur. K70N/T/S, which are not on the SDRM but are associated with low-level TDF resistance, occurred in 3 individuals including 1 without an SDRM.
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HIV Mutation Detail Information