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Mutation Information
|
Mutation Site
|
L74I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
dolutegravir (DTG) |
Literature Information
|
PubMed PMID
|
27539455
|
|
Published Year
|
2016 |
|
Journal
|
Infectious diseases and therapy |
|
Title
|
New Antiretroviral Treatment for HIV. |
|
Author
|
Badowski ME,Pérez SE,Biagi M,Littler JA |
|
Evidence
|
The efficacy of dolutegravir twice daily is reduced in the presence of INSTI-resistance Q148 substitution along with two or more additional INSTI-resistance substitutions including T66A, L74I/M, E138A/K/T, G140S/A/C, Y143R/C/H, E157Q, G163S/E/K/Q, or G193E/R.
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HIV Mutation Detail Information