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Mutation Information
|
Mutation Site
|
L74I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PreS1 |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
AF286594.1
|
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
20119580
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B;
Liver cirrhosis;
Hepatocellular carcinoma
|
|
Published Year
|
2010 |
|
Journal
|
Journal of Korean medical science |
|
Title
|
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations. |
|
Author
|
Kim JH,Jung YK,Joo MK,Kim JH,Yim HJ,Park JJ,Kim JS,Bak YT,Yeon JE,Byun KS |
|
Evidence
|
G2A (n=1), G73D (n=1), L74I (n=2), A91T (n=1), and A95T (n=1) mutations were detected in Group P. In Group C, A81T (n=1), T86A (n=2), and A95V (n=1) mutations were detected. Three cases of I84T mutations were found in Group C, compared to only one in Group P (Fig. 1).
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|
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HBV Mutation Detail Information