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Mutation Information
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Mutation Site
|
L74F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
INSTIs |
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Country
|
Russia |
Literature Information
|
PubMed PMID
|
32752001
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Viruses |
|
Title
|
Genetic Features of HIV-1 Integrase Sub-Subtype A6 Predominant in Russia and Predicted Susceptibility to INSTIs. |
|
Author
|
Kirichenko A,Lapovok I,Baryshev P,van de Vijver DAMC,van Kampen JJA,Boucher CAB,Paraskevis D,Kireev D |
|
Evidence
|
In most sequences of sub-subtype A1 and subtype B, this position was encoded by the CTG, which determined the genetic barrier to 74M and 74I with scores of 2.5 and 2.7, respectively. For position L74F, A6 sequences had a score of 5, while for sequences of A1 and B, the barrier had a score of 3.5.
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HIV Mutation Detail Information