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Mutation Information
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Mutation Site
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L72R |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vif |
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Viral Reference
|
K03455.1
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Literature Information
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PubMed PMID
|
31665623
|
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Published Year
|
2019 |
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Journal
|
Cell reports |
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Title
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HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators. |
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Author
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Salamango DJ,Ikeda T,Moghadasi SA,Wang J,McCann JL,Serebrenik AA,Ebrahimi D,Jarvis MC,Brown WL,Harris RS |
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Evidence
|
Likewise, L72R, G75T, Q83H, Q105R, and N140Y were predicted to have no effect on degradation, and all reduced both EGFP-PPP2R5A and APOBEC3G-EGFP to levels comparable with those caused by wild-type Vif (Figure 1E).
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HIV Mutation Detail Information