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Mutation Information
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Mutation Site
|
L67R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E7 |
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Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
NC_001526.3
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Literature Information
|
PubMed PMID
|
32183180
|
|
Published Year
|
2020 |
|
Journal
|
Viruses |
|
Title
|
Suppression of a Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via a Cyclin Dependent Kinase 8-Dependent Mechanism. |
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Author
|
Rice S,Kim SM,Rodriguez C,Songock W,Raikhy G,Lopez R,Henderson L,Yusufji A,Bodily J |
|
Evidence
|
Certain mutations of the hydrophobic core residues of CR3, such as L67R, are reported to disrupt E7's association with host factors but this may be due to significant structural changes of the C terminus rather than disruption of specific binding residues on E7.
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HPV Mutation Detail Information