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Mutation Information
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Mutation Site
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L677I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gp41 |
Literature Information
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PubMed PMID
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33552873
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Published Year
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2021 |
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Journal
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) |
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Title
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Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV-1 Env Clustering. |
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Author
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Nieto-Garai JA,Arboleya A,Otaegi S,Chojnacki J,Casas J,Fabriàs G,Contreras FX,Kräusslich HG,Lorizate M |
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Evidence
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For this purpose, the "LWYIK" CRAC domain in the full-length gp41 was disrupted by introducing a conservative mutation (L677I) that has been described to hamper interaction of CRAC-derived peptides with chol, and to cause an inhibition of fusion in cells expressing the gp41 CRAC mutant.[ 48 ] Viral particles containing this mutation were purified, and chol interaction was studied.
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HIV Mutation Detail Information